Updated on March 8, 2026 by Dr. Diana Rangaves. To give you technically accurate, evidence-based information, content published on the Everlywell blog is reviewed by credentialed professionals with expertise in medical and bioscience fields.
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Table of contents
- What Is Ozempic®?
- Ozempic® Side Effects
- How Long Do Ozempic® Side Effects Last?
- What Influences the Duration of Side Effects From Ozempic®?
- What To Do in Case of an Overdose
- Getting Support on Your Weight Loss Journey
- Related Content
Ozempic® is an FDA-approved medication used alongside diet and exercise to help manage blood sugar levels in adults with type 2 diabetes. It may also reduce the risk of major cardiovascular events such as heart attack or stroke in adults with type 2 diabetes and known heart disease.[1]
Like many medications, Ozempic® can cause side effects, especially when you first begin treatment. These symptoms often occur as the body adjusts to the medication and typically improve over time. In many cases, side effects last only a few days to a few weeks.
Understanding what side effects may occur—and how long they may last—can help you better prepare for treatment and know when to speak with a healthcare provider.
What Is Ozempic®?
Ozempic®, also known as semaglutide, belongs to a class of medications called glucagon-like peptide-1 (GLP-1) receptor agonists. These medications mimic the GLP-1 hormone that is naturally released in the gastrointestinal tract after eating.[1]
One of the main roles of GLP-1 is to stimulate insulin secretion, which helps lower blood sugar levels. GLP-1 activity can also signal the brain to reduce appetite and promote a feeling of fullness.[1]
Ozempic® is typically administered once weekly on the same day each week. It can be taken at any time of day, with or without food. If you miss a dose, it should be administered as soon as possible within five days of the missed dose.
FDA-approved uses of Ozempic® (on-label):
- Improve glycemic control in adults with type 2 diabetes when used alongside diet and exercise
- Reduce the risk of major cardiovascular events in adults with type 2 diabetes and known cardiovascular disease
Non-FDA-approved uses (off-label):
- Weight loss[2]
Ozempic® Side Effects
Like most medications, Ozempic® may cause side effects. Many of these effects are mild and improve after a few days or weeks as the body adjusts to the medication. In rare cases, symptoms may worsen or require medical attention.[3]
Some side effects occur because the medication slows digestion, which can cause food to remain in the stomach longer. This process may contribute to symptoms such as nausea or vomiting.[4]
If side effects become severe or persist, it is important to contact your healthcare provider.
Common side effects:
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Constipation
- Heartburn
- Burping
Severe side effects:
- Rash, itching, or swelling of the eyes
- Fainting or dizziness
- Decreased urination or swelling in the legs
- Vision changes
- Light-headedness, sweating, or confusion
- Severe upper stomach pain
How Long Do Ozempic® Side Effects Last?
The duration of Ozempic® side effects varies depending on factors such as overall health, existing medical conditions, and the specific symptoms experienced.
Many common side effects appear during the first few days after starting the medication and improve within days or weeks as the body adapts.
In rare cases, some side effects may persist or require additional management. Examples may include:
- Thyroid cancer
- Diabetic retinopathy
Before beginning treatment, it’s important to discuss potential side effects and expected timelines with your healthcare provider.
What Influences the Duration of Side Effects From Ozempic®?
Several factors may affect how long side effects last.
- Medication interactions: Taking Ozempic® alongside other medications may increase or worsen side effects.
- Pre-existing health conditions: Certain health conditions may influence how the body responds to the medication.
- Individual variation: Genetics, lifestyle, and overall health can affect how each person experiences side effects.
- Dosage adjustments: Increasing dosage levels under medical supervision may influence symptom intensity or duration.
What To Do in Case of an Overdose
An overdose may occur if Ozempic® is taken outside the prescribed dosing schedule. If an overdose is suspected, call the Poison Control helpline at 1-800-222-1222.
Call 911 or emergency services immediately if someone has collapsed, experienced a seizure, or is having difficulty breathing.
Getting Support on Your Weight Loss Journey
If you’re considering medications like semaglutide or experiencing side effects while taking Ozempic®, working with a healthcare provider can help you better understand your options. A provider can review your health history, monitor how your body responds to treatment, and help adjust your plan if side effects become difficult to manage.
Many people now explore weight management support through telehealth services, which allow you to connect with licensed providers, discuss medication options, and receive ongoing guidance from home.
Related Content
Ozempic® Nausea Relief: What to Know
Can You Take Ozempic® While Pregnant?
Jardiance® vs. Ozempic®: Similarities and Differences
Related Content
Victoza® vs. Ozempic® Compared
How to Get Ozempic® Covered by Insurance
Ozempic® and Pregnancy: What You Need to Know
References
- FDA. Medications containing semaglutide marketed for type 2 diabetes or weight loss. Last reviewed January 10, 2024. Accessed January 18, 2024. https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/medications-containing-semaglutide-marketed-type-2-diabetes-or-weight-loss
- Han SH, Safeek R, Ockerman K, et al. Public interest in the off-label use of glucagon-like peptide 1 agonists (Ozempic) for cosmetic weight loss: a Google trends analysis. Aesthet Surg J. 2023;44(1):60-67. doi:10.1093/asj/sjad211
- Mayo Clinic. Semaglutide (subcutaneous route) side effects. Last updated December 1, 2023. Accessed January 19, 2024. https://www.mayoclinic.org/drugs-supplements/semaglutide-subcutaneous-route/side-effects/drg-20406730?p=1
- Jensterle M, Ferjan S, Ležaič L, et al. Semaglutide delays 4-hour gastric emptying in women with polycystic ovary syndrome and obesity. Diabetes Obes Metab. 2023;25(4):975-984. doi:10.1111/dom.14944
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